Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation
20th March 2025
Yun-Ho Choi 1, Guang-Hai Yan, Ok Hee Chai, Chang Ho Song (2010) This article discusses the inhibitory effects of curcumin (the active component of turmeric) on mast cell activation and histamine release in mast cell-mediated allergic responses. It highlights curcumin’s mechanisms, including suppression of calcium influx and enhancement of intracellular cAMP levels, which reduce mast cell degranulation and histamine release. The findings suggest curcumin’s potential therapeutic role in managing mast cell-associated allergic diseases.
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