Prevalence of mast cell activation disorders and hereditary alpha tryptasemia among patients with postural orthostatic tacycardia syndrome and Ehlers-Danlos syndrome: A systematic review
14th July 2025
Matthew Farley, Ricardo J. Estrada-Medisabel, Emily A. Gansert, Dayne Voelker, Lisa A. Marks, Alexei Gonzalez-Estrada (2025). This article systematically reviews the prevalence of mast cell activation disorders (MCADs) and hereditary alpha tryptasemia (HAT) in patients with postural orthostatic tachycardia syndrome (POTS) and Ehlers-Danlos syndrome (EDS). It finds that no studies that met strict diagnostic criteria confirm a clear association. Despite anecdotal reports and individual studies suggesting potential overlap between these conditions, most existing research lacked validated diagnostic standards and consistency. The article concludes that more rigorous, well-designed studies are needed to determine whether a true clinical relationship exists among POTS, EDS, MCADs, and HAT.
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