Mast Cell Activation Syndrome (MCAS) forms part of a spectrum of mast cell disorders caused by the abnormal proliferation, accumulation, function and/or activation of mast cells. It causes a wide range of unpleasant, frequently debilitating allergic and inflammatory symptoms in many different systems of the body.
People with MCAS can react to a wide range of triggers and potentiating factors including foods, chemicals, drugs, fragrances, temperature, exercise, stress, hormonal fluctuations and infection.
The onset of MCAS can be unpredictable, affecting both children and adults, and presents with a wide range of symptoms in multiple body systems, ranging from hives and rashes, respiratory problems, syncope, gastrointestinal pain, diarrhoea, reflux, neurological problems including anxiety and brain fog, bone pain, and anaphylaxis.
The complex, multisystem nature of MCAS can make gaining a diagnosis particularly challenging. The ability to gain a diagnosis is also negatively impacted by a lack of universally accepted diagnostic criteria and access to diagnostic biomarkers.
There is an urgent need to give a voice to patients, support doctors and researchers, and inform policy-makers about this widely under-recognised condition.
With your support, we feel confident that we can make a substantial difference to the lives of MCAS sufferers and their families.
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