Comorbidities

We know that navigating MCAS can sometimes feel like a maze and sometimes, it's not just about managing MCAS itself; it's about understanding the other conditions that might accompany it. Research has shown that, those living with MCAS may also have conditions such as Ehlers Danlos Syndrome (EDS), Marfan syndrome, dysautonomia, Postural Orthostatic Tachycardia Syndrome (POTS), and Type 2 diabetes. The relationship between MCAS and many of these comorbidities is yet to be fully understood, and more research is needed to help us learn more.

Ehlers Danlos Syndrome (EDS)

EDS is a group of connective tissue disorders characterised by joint hypermobility, skin hyperextensibility, and tissue fragility. Some individuals living with MCAS also have EDS, or may have a diagnosis of hypermobility. Both EDS and MCAS share common symptoms such as joint pain, and gastrointestinal issues.

You can find out more about EDS here.

Marfan Syndrome

Marfan syndrome is a connective tissue disorder that affects the skeletal, cardiovascular, and ocular systems. Some individuals living with MCAS may also have Marfan syndrome. Both conditions can manifest with symptoms such as cardiovascular and musculoskeletal issues.

You can read more about Marfan syndrome here. 

Postural Orthostatic Tachycardia Syndrome (PoTS)

POTS is a form of dysautonomia characterised by an abnormal increase in heart rate upon standing. Both MCAS and POTS share overlapping symptoms such as dizziness, lightheadedness, fatigue, and gastrointestinal disturbances. In addition to POTS, individuals may also experience other forms of dysautonomia, such as neurocardiogenic syncope and orthostatic hypotension.

You can read more about PoTS here.

Type 2 Diabetes

Diabetes is a metabolic disease. Mast cells are implicated in metabolic diseases. Fatigue is often experienced by those with MCAS and those with Type 2 Diabetes.

Further research is needed to understand the connection between MCAS and Type 2 Diabetis.

You can read more about Type 2 Diabetes here.