Diet and MCAS
Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E
S. N. Pramod, Y. P. Venkatesh and P. A. Mahesh (2007). This study addresses the role of potato lectin (STA) in activating mast cells and basophils through non-specific binding to IgE and FcεR receptors. It studies the effect of STA on atopic and non-atopic subjects, and finds that it may cause non-allergic hypersensitivity in some atopic individuals, despite not being a ‘true allergen’. Therefore, it suggests that lectins in foods like potatoes and tomatoes may contribute to symptoms of allergic reactions (e.g. asthma) in STA-sensitive individuals.
Effect of Dietary Fiber and Metabolites on Mast Cell Activation and Mast Cell-Associated Diseases
Jelle Folkerts, Ralph Stadhouders, Frank A Redegeld, See-Ying Tam, Rudi W Hendriks, Stephen J Galli, Marcus Maurer (2018). This article provides an overview of current understandings surrounding the effects of dietary fibre on the regulation of mast cell activity and mast cell-associated diseases. It discusses the potential therapeutic effects of fibre and its metabolites (including short-chain fatty acids) on mast-cell associated airway inflammation and allergic diseases. It proposes further research to explore the role of dietary fibre in preventing and treating conditions associated with mast cell activation.
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